Prolotherapy is a regenerative injection technique that repairs arthritic joints, and strengthens injured ligaments or tendons.

Chronic pain is often caused by joint laxity or ligamentous laxity, and the treatment for this increased laxity is prolotherapy.

Prolotherapy involves injecting a proliferant solution (typically 12.5-25% dextrose) with a local anesthetic (lidocaine) into damaged connective tissue such as ligaments, tendons or cartilage. This treatment causes localized inflammation at the desired site of injury which stimulates the body to repair the tissue. Prolotherapy typically involves a series of 2-6 treatments at 3-6 week intervals. Benefits from this treatment are typically noticed 3-4 weeks after the first or second treatment.

Patients are asked to stop taking NSAIDs (Ibuprofen, Aleve, Advil, Naproxen, Mobic etc..) one week prior and four weeks after injections for optimal healing response.

Conditions commonly treated with prolotherapy:

  • Neck pain
  • Thoracic pain
  • Rib pain
  • Lumbar pain
  • Sacral or SI (sacroiliac) joint pain
  • Knee osteoarthritis
  • Knee meniscus injury or degeneration
  • Knee ligament injury (MCL, LCL, ACL, PCL)
  • Patellofemoral syndrome or chondromalacia patella
  • Sports Hernia
  • Groin Pain or Athletic Pubalgia
  • Degenerative Disc Disease or Arthritis of the Spine
  • De Quervain’s Tenosynovitis
  • Shoulder pain caused by labrum or rotator cuff injury
  • Hip pain caused by osteoarthritis, labrum injury, or tendinosis.
  • Wrist pain
  • Shin Splints
  • Patellar tendinosis
  • Joint pain in the hands or feet
  • TMJ (Temporomandibular Joint Disorder)
  • Baker’s Cyst
  • Over Manipulation Syndrome
  • Tennis Elbow
  • Golfer’s Elbow

Prolotherapy Research:

The following is a link by Dr. Dean Reeves, MD which nicely summarizes prolotherapy research articles.